Lecture 'Autoreactive B cells in rheumatic disease, what makes them different?'

For whom
Alumni , Business , Employees , Students
07-10-2022 from 11:30 to 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research

René E. M. Toes (Leiden University Medical Center) will discuss their work on autoreactive antibodies and humanB cells in rheumatic disease.

Dysregulation of B cells hallmarks many systemic autoimmune diseases. This is evidenced the presence of disease-specific autoantibodies and the remarkable therapeutic effect of B cell depletion. Rheumatoid Arthritis (RA), but also several other rheumatic autoimmune diseases share these characteristics. Nonetheless, our recent evidence indicates that different mechanisms responsible for the breach of tolerance are at play in different diseases. For example, we have found that more than 90% of the autoantibodies hallmarking RA are glycosylated in their variable domains. The lack of immunological remission, despite clinical remission is relevant for the design of interventions aiming to silence the autoimmune response. The reasons and consequences of the features displayed by autoreactive antibodies and B cells will be discussed.

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