Lecture 'Resolving the ontogeny and function of placental macrophages'

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Alumni , Business , Employees , Students
21-10-2022 from 11:30 to 12:30
UGent-VIB-onderzoeksgebouw, Technologiepark 71, 9052 Zwijnaarde
VIB-UGent Center for Inflammation Research

Placental macrophages and how they are thought to play a role in placental development by Naomi McGovern (University of Cambridge, UK)

The human placenta is a major organ that regulates the health of both the mother and fetus during pregnancy. It also acts as a crucial physical barrier, protecting the fetus from infection. The placenta consists of two sides: the maternal and the fetal side. While most human organs contain a diverse array of immune cells, the fetal side of the placenta only contains one population of fetal-derived immune cells, macrophages termed Hofbauer cells (HBC). HBC are highly abundant within the placenta and are thought to play an important role in placental development.

However, our understanding of HBC lags far behind the rest of the macrophage field. We have characterised the progenitors that generate HBC and determined how the properties of HBC adapt to meet the changing needs of the placenta across gestation. Furthermore, we have demonstrated how these changes in HBC properties contribute to the late presentation of listeriosis during pregnancy.

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