Doctoral fellow

Last application date
Dec 31, 2022 00:00
Department
FW03 - Department of Bio-Analysis
Contract
Limited duration
Degree
Master of Pharmaceutical Care, Master of Medicine, Master of Biomedical Sciences, Master of Drug Development
Occupancy rate
100%
Vacancy type
Research staff

Job description

PhD in Genomics for Public Health within the research group of Prof. Lies Lahousse. Genomics has become increasingly relevant in chronic complex diseases, including in cancer medicine. Next-generation sequencing technologies and analytical approaches are now being introduced into the clinic with a multitude of applications, ranging from identifying individual targetable genetic alterations to monitoring treatment response. This PhD project aims to improve our understanding of the individual susceptibility to develop a chronic complex disease or certain types of cancer. By increasing our understanding of the role of genetic variants in diagnosis and treatment response, we ultimately aim to promote the application of genomics to improve diagnosis and treatment of patients with a chronic complex disease.
The PhD student will have the opportunity to work within a granted multi-disciplinary consortium (including organizations from 17 EU countries) with efforts for training and education to raise awareness of the importance of genomics among healthcare professionals, patients, and the public. The final goal of this consortium is to establish recommendations for initiatives into the EU health system that will further improve the access of individuals and patients to prevention, diagnosis, and treatment of cancer through personalized medicine. The PhD student will therefore list and collect genetic data and list clinical decision support systems using genetic and environmental data to predict disease onset. The PhD student will learn more about genome-wide association studies and polygenic risk scores in coordination with consortium and team members.
The research team of Prof. Lies Lahousse performs population-based research focused on precision medicine including optimizing the benefit risk ratio of approved drugs by studying heterogeneity among phenotypes, endotypes and underlying genetics with the ultimate goal of improving care of patients with chronic complex diseases. With expertise in pharmacoepidemiology, clinical respiratory epidemiology and genetic epidemiology, the team explores clinical and genetic disease determinants with special interest for environmental and pharmacological interactions. The team has vast experience in data mining and statistics, study design, multivariable logistic and linear regression analyses, longitudinal analyses (survival analyses and mixed-effects models), omicsanalyses, genome-wide association studies, and pharmacogenetic studies.

Job profile

  • You demonstrate interest in genomics, public health, and health care. Publications or a master's thesis in genetics, epidemiology, precision medicine or care of patients with chronic complex diseases (e.g. cancer, COPD) are recommended. Knowledge of, and affinity with, current developments in health care (both in the Belgian context and internationally) is required.
  • You are interested or experienced in statistical data processing and have knowledge of R or SPSS.
  • You achieved excellent study results and have excellent English communication skills (both oral and written).
  • You can take initiative, have perseverance and strong mathematical and analytical skills.
  • You have an independent, problem-solving, organized and result-oriented attitude.
  • You are highly motivated and can plan and conduct research accurately.
  • You have the required social skills, flexibility, and critical mind to function in a multidisciplinary and international academic environment.

We offer a full-time, fixed-term appointment for initially 12 months, renewable after positive evaluation and approval up to 4 years. Starting date is January 1st 2023 at earliest and November 1st 2023 at latest.
A competitive salary including benefits is offered, salary levels account for years of professional experience.
As Ghent University maintains an equal opportunities and diversity policy, everyone is encouraged to apply for this position.

How to apply

Please send a single pdf to Lies.Lahousse@UGent.be combining:

  • 1-page motivation letter expressing your interest and suitability.
  • CV including Master thesis title and DOI in case of publications.
  • Transcript of your Masters’ degrees with overview of your study results (or Certificate of equivalence if applicable).

Applications are welcome until the position is filled. A shortlist of applicants will be selected and invited for interviews (from December 20th to January 18th).