Natural killer cell lab

Research Domain

  • Developmental immunology.
  • Differentiation of human natural killer(NK) cells and innate lymphoid cells (ILC).


Research Topics

NK cells have been shown to have high cytotoxic potential against various cancer cell types, and are currently used in the clinic for treatment of cancer patients. Whereas a lot is known regarding differentiation and function of murine NK cells, current knowledge regarding human NK cells is limited. Our aim is to reveal the role of several transcription factors in the differentiation of human hematopoietic stem cells into mature NK cells, and in the maintenance and function of mature NK cells.