Background and research focus


4Brain is a multidisciplinary research group focusing on translational neuroscientific research in epilepsy, stroke, Multiple Sclerosis, and cognitive problems, with a specific expertise on neuromodulation.

Research focus

Neuroscientists within 4BRAIN focus on translational neuroscience to unravel the pathophysiology of neuropsychiatric disorders and to develop novel therapies. Multimodal neuroscience techniques are used to excel in the neuroscience field and bridge preclinical and clinical research. The focus of our preclinical research is on advanced recording and neuromodulation techniques in various models for neuropsychiatric diseases to understand their pathogenesis and search for new treatments. The focus of our clinical research is on multimodal clinical techniques including neurophysiology, imaging and neuropsychology and on the modulation of aberrant brain function using both non-invasive and invasive neuromodulatory treatments.


Professors and Guest Professors

Paul Boon, Evelien Carrette (contact person), Veerle De Herdt, Guy Laureys, Alfred MeursMarijke MiattonRobrecht Raedt, Kristl Vonck, Wytse Wadman

Postdoctoral researchers

Lars Emil Larsen, Mathieu Sprengers, Wouter Van Lysebettens

PhD candidates

Anirudh Acharya, Helen Bachmann, Charlotte Bouckaert, Sofie Carrette, Emma Christiaen (Department of Electronics and information systems), Erine Craey, Elien De Cock, Jana Desloovere, Stefanie Gadeyne, Charlotte Germonpré, Marie-Gabrielle Goossens, Stephanie Hödl, Simona Manzella, Ana Martos Martinez-Caja (Department of Nutrition, Genetics and Ethology), Ann Mertens, Lien Naert (Department of Experimental psychology), Silke Proesmans, Ruben Schoeters (Department of Information technology), Anne Sieben (Ghent University Hospital), Jeroen Spanoghe, Latoya Stevens, Nicolas Vandenbussche (Ghent University Hospital), Liesbeth Van Hijfte (Ghent University Hospital), Kristof Verhoeven (Ghent University Hospital)

Technical staff

Ine Dauwe (Ghent University Hospital), Jeroen Van Aken (extern)

National and international collaborations



  • GHEP-lab: Chris Baeken, Marie-Anne Vanderhasselt 

  • Infinity: Chris Vanhove 

  • Department for Microsystems Technology (CMST): Jan Van Fleteren,  Frederik Leys 

  • Medicinal Chemistry: Serge Van Calenberg

KU Leuven 

  • Laboratory for Neuro- and Psychophysiology: Marc Van Hulle 

  • Research Group for Neurobiology and Gene Therapy: Veerle Baekelandt 

  • NERF: Fabian Kloosterman


  • Center for Neurosciences: Ilse Smolders, Dimitri De Bundel, Ann Massie, Ann Van Eeckhaut  (formal longstanding collaboration via AMIE) 


  • Laboratoire de Cartography fonctionelle du Cerveau & MEG unit


  • Institute for Neuroscience: Philippe Gailly, Jean-Noel Octave


  • Technical University Eindhoven: Bert Aldenkamp, Jan Bergmans, Rob Mestrom, Sveta Zinger, Maarten Paulides, Massimo Mischi, … 
  • Donders Institute: Lennart Verhagen 
  • University of IRVINE: Bruce McNaughton 
  • University of Barcelona: Francisco Ciruela

Defended PhDs (last 5 years)

Proteinopathies of front-temporal lobar degeneration: investigating the impact of vascular contributions 

Anne Sieben (2021)

Dysphagia, dysarthria and aphasia post-stroke: from epidemiology to technology-delivered aphasia therapy

Elien De Cock (2021)

Chemogenetic neuromodulation in a rat model of epilepsy

Marie-Gabrielle Goossens (2021)

Temperature as a confounder on vagus nerve stimulation induced brain excitability modulation in rats 

Wouter Van Lysebettens (2020)

Deep brain stimulation for drug-resistant epilepsy: efficacy and mechanism of action

Mathieu Sprengers (2020)

The potential of multimodal neuroimaging to personalize transcranial magnetic stimulation treatment protocols

Debby Klooster (2019)

Understanding consumers' food experience through measurement of explicit and implicit responses

Sofie Lagast (2017)

MEG and MRI in diagnostics of epilepsy: an explorative study in novel approaches of epilepsy diagnostics

Albert Colon (2017)

Investigation of a role of uric acid in experimental seizure models

Lisa Thyrion (2016)

Investigation of the neurophysiological mechanisms of vagus nerve stimulation

Lars Emil Larsen (2016)

Event-related potentials in patients with refractory epilepsy

Leen De Taeye (2015)

Vagus nerve stimulation for epilepsy and depression: mechanism of action and stimulation parameters

Annelies Grimonprez (2015)

Electrical cortical stimulation, and the RF-amide and orexin neuropeptide systems as alternative treatments in refractory epilepsy

Ine Buffel (2015)

Hippocampal deep brain stimulation for drug resistant epilepsy in a rodent model

Bregt Van Nieuwenhuyse (2015)