Development of new NMR experiments to measure homonuclear couplings

1H-1H scalar couplings are a double-edged sword. They provide valuable information for stereochemical, conformational and even isotope analyses. However, the simultaneous presence of many couplings leads to intricate multiplets and spectral overlap, preventing accurate coupling extraction. Pure shift methods are recently emerging experiments that provide fully homodecoupled NMR spectra, thus resolving the spectral overlap issue [1]. Unfortunately, these methods also remove all valuable coupling information. Our aim is to develop new experiments that build on pure shift methods, but still allow measuring the 1H-1H couplings, either individually [2] or as full multiplets [3]. Besides scalar couplings, we are also investigating the use of such methods to gain access to long-range 1H-1H residual dipolar couplings.